Synthetic Biology
Systems Biology

Measuring gene expression in single cells.
Learn more

Synthetic Biology
Systems Biology

Play the DNA factory game
Learn more

Synthetic Biology
Systems Biology

Keeping synthetic biology safe.
Learn more

Synthetic Biology
Systems Biology

Optimizing gene synthesis
Learn more

Synthetic Biology
Systems Biology

Designing synthetic DNA molecules.
Learn more

NIH proposal gets amazing score

bigstock--D-man-running-after-dollar-sy-51195964

The proposal to renew the funding supporting our collaboration with John Tyson was examined by the NIH study section last week. We got a score of 18, which places in the top 2%. At NIH a good score is a small score! This is the best score we got any proposal we submitted to NIH. […]

Ebola Vaccine Update

Ebola_virus_virion

The development of vaccines against emerging diseases has been on my radar screen for several years as a potential biomedical applications of GenoCAD. The week has been rich in surprising stories about the development of an Ebola vaccine. The NY Times reported that an Ebola vaccine candidate had been developed 10 years ago. It showed […]

Get our Standard Operating Procedures

Many people have expressed interest in learning more about the way we run the lab after the publication in PLoS Computational Biology of  ”If You Can’t Measure It, You Can’t Manage It“. Initially, we released them on this web site as individual posts for each SOP. That did not work too well. They took too […]

Releasing a list of synthetic biology blogs

I thought it might be useful to compile a list of Synthetic Biology blogs that can be used as alternative sources of information and perspectives complementing academic journals. This list was initially seed with contributions from Nathaniel Gore  and Devin Camenares. It was later expanded by submissions from the community. Do you know another SynBio blog that […]

Synthetic Biology Blogs

Person reading RSS news. Image contain clipping path

I thought it might be useful to compile a list of Synthetic Biology blogs that can be used as alternative sources of information and perspectives complementing academic journals.  This list was prepared using contributions from Nathaniel Gore  and Devin Camenares. Do you know other SynBio blogs that should be added to the list? Use the comments below to suggest […]

ACS Synthetic Biology: this month articles

images

ACS Synthetic Biology is progressively rapidly gaining traction in the synthetic biology community as a journal of choice for publishing papers relevant to our community. I thought it might be useful to identify articles that have  generated the most “buzz” in the last 30 days. Below are the articles that have been mentioned in social […]

ACS Synthetic Biology: all articles

images

ACS Synthetic Biology is progressively rapidly gaining traction in the synthetic biology community as a journal of choice for publishing papers relevant to our community. I thought it might be useful to identify articles that have  generated the most “buzz”. Below are the articles that have been mentioned in social media at any time. Click on […]

A Guide for Communicating Synthetic Biology

your voice

The Woodrow Wilson Center Synthetic Biology Project has just released a guide to help practitioners of synthetic biology communicate with different constituencies. Reading this document is cheap insurance against potential public relation disasters that may hurt not only you and your organization but our entire industry. We certainly do not want or need a major […]

Synthetic Biology: Patent or not Patent?

Intellectual property and related words in word collage

Synthetic biology has emerged at the interface between life sciences and engineering. This has a resulted in a cultural divide regarding the status of intellectual property. Engineers have been advocating an open source model that has been spectacularly successful in computer science. Life scientists and specifically biotechnology companies have been defending the patenting of DNA […]

CRISPR-Cas9:Rational design of highly active sgRNAs

journal_header_v3

A group led by David Root from the Broad Institute published a nice paper published in Nature Biotechnology (10.1038/nbt.3026) describing a predictive model of the sgRNA target sequence cleavage efficiency.  They created a pool of sgRNAs, tiling across all possible target sites of a panel of six endogenous mouse and three endogenous human genes and quantitatively […]