I want to tell you how cyber-infrastructures can enable large research research projects involving specialists from multiple disciplines and why it makes economic sense to develop such an infrastructure. The most exciting scientific research often involves multiple disciplines. You may have heard of multidisciplinary research, interdisciplinary research, or transdisciplinary research. They are like different levels of intimacy […]
This file can be imported into GenoCAD for the design of synthetic transcription factors (sTFs) in eukaryotic cells. Knowledge derived from experimental evidence was captured in this grammar to guide the user to create designer transcription factors that should operate as intended. The grammar [...]
Virginia Tech’s program in computational biology was featured during the 2013 meeting of the American Society For Cell Biology. The YouTube video below was broadcast on the conference closed-circuit TV channel.
The interplay of mathematical modelling with experiments is one of the central elements in systems biology. The aim of reverse engineering is to infer, analyse and understand, through this interplay, the functional and regulatory mechanisms of biological systems. Reverse engineering is not exclusive of systems [...]
This is a grammar that can be imported into the web-based application GenoCAD to design expression vectors for expressing genes in the chloroplast of Chlamydomonas reinhardtii. Please refer to the publication linked to this entry for more information about this dataset.
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We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic chromosome. The [...]
MOTIVATION: Expression vectors used in different biotechnology applications are designed with domain-specific rules. For instance, promoters, origins of replication, or homologous recombination sites are host-specific. Similarly, chromosomal integration or viral delivery of an expression cassette impose specific structural constraints. As de novo gene synthesis and [...]